Skip to content

Enum: BioprocessOptimizationType

Strategies and approaches for optimizing biomanufacturing processes to improve yield, productivity, and product quality

URI: valuesets:BioprocessOptimizationType

View in BioPortal

Permissible Values

Value Meaning Description Close Mappings Broad Mappings Approaches Technologies
MEDIA_OPTIMIZATION Optimization of growth media composition including carbon sources, nitrogen sources, and micronutrients
STRAIN_ENGINEERING Genetic modification and selection of production strains for improved performance metabolic engineering, directed evolution, adaptive laboratory evolution
PROCESS_INTENSIFICATION Engineering approaches to increase volumetric productivity and reduce process footprint
CONTINUOUS_PROCESSING Conversion from batch to continuous operation for improved efficiency and consistency
FED_BATCH_OPTIMIZATION Optimization of feeding strategies in fed-batch processes to maximize product yield
DOWNSTREAM_PURIFICATION Optimization of product recovery and purification processes OBI:0001505 chromatography, membrane separation, extraction
IN_LINE_ANALYTICS Implementation of real-time process analytical technology (PAT) for process monitoring and control PROCO:0000227 Raman spectroscopy, NIR, online HPLC
DIGITAL_TWIN_MODELING Use of computational process models for simulation, prediction, and optimization mechanistic models, hybrid models, machine learning

Slots

Name Description
bioprocess_optimization Type of bioprocess optimization strategy

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/valuesets

LinkML Source

name: BioprocessOptimizationType
instantiates:
- valuesets_meta:ValueSetEnumDefinition
description: Strategies and approaches for optimizing biomanufacturing processes to
  improve yield, productivity, and product quality
title: Bioprocess Optimization Type
from_schema: https://w3id.org/valuesets
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: DRAFT
rank: 1000
permissible_values:
  MEDIA_OPTIMIZATION:
    text: MEDIA_OPTIMIZATION
    description: Optimization of growth media composition including carbon sources,
      nitrogen sources, and micronutrients
  STRAIN_ENGINEERING:
    text: STRAIN_ENGINEERING
    description: Genetic modification and selection of production strains for improved
      performance
    annotations:
      approaches:
        tag: approaches
        value: metabolic engineering, directed evolution, adaptive laboratory evolution
  PROCESS_INTENSIFICATION:
    text: PROCESS_INTENSIFICATION
    description: Engineering approaches to increase volumetric productivity and reduce
      process footprint
  CONTINUOUS_PROCESSING:
    text: CONTINUOUS_PROCESSING
    description: Conversion from batch to continuous operation for improved efficiency
      and consistency
  FED_BATCH_OPTIMIZATION:
    text: FED_BATCH_OPTIMIZATION
    description: Optimization of feeding strategies in fed-batch processes to maximize
      product yield
  DOWNSTREAM_PURIFICATION:
    text: DOWNSTREAM_PURIFICATION
    description: Optimization of product recovery and purification processes
    annotations:
      approaches:
        tag: approaches
        value: chromatography, membrane separation, extraction
    broad_mappings:
    - OBI:0001505
  IN_LINE_ANALYTICS:
    text: IN_LINE_ANALYTICS
    description: Implementation of real-time process analytical technology (PAT) for
      process monitoring and control
    annotations:
      technologies:
        tag: technologies
        value: Raman spectroscopy, NIR, online HPLC
    close_mappings:
    - PROCO:0000227
  DIGITAL_TWIN_MODELING:
    text: DIGITAL_TWIN_MODELING
    description: Use of computational process models for simulation, prediction, and
      optimization
    annotations:
      approaches:
        tag: approaches
        value: mechanistic models, hybrid models, machine learning