Enum: CellCycleCheckpoint

Cell cycle checkpoints that regulate progression

Permissible Values

Value	Meaning	Description
G1_S_CHECKPOINT	GO:0000082	G1/S checkpoint (Restriction point)
INTRA_S_CHECKPOINT	GO:0031573	Intra-S checkpoint
G2_M_CHECKPOINT	GO:0031571	G2/M checkpoint
SPINDLE_CHECKPOINT	GO:0031577	Spindle checkpoint (M checkpoint)

Slots

Name	Description
cell_cycle_checkpoint	Cell cycle checkpoints that regulate progression

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: CellCycleCheckpoint
description: Cell cycle checkpoints that regulate progression
from_schema: https://w3id.org/linkml/valuesets
rank: 1000
permissible_values:
  G1_S_CHECKPOINT:
    text: G1_S_CHECKPOINT
    description: G1/S checkpoint (Restriction point)
    meaning: GO:0000082
    annotations:
      aliases:
        tag: aliases
        value: Start checkpoint, Restriction point, R point
      regulator:
        tag: regulator
        value: p53, Rb
    title: G1/S transition of mitotic cell cycle
  INTRA_S_CHECKPOINT:
    text: INTRA_S_CHECKPOINT
    description: Intra-S checkpoint
    meaning: GO:0031573
    annotations:
      function:
        tag: function
        value: monitors DNA replication
      regulator:
        tag: regulator
        value: ATR, CHK1
    title: mitotic intra-S DNA damage checkpoint signaling
  G2_M_CHECKPOINT:
    text: G2_M_CHECKPOINT
    description: G2/M checkpoint
    meaning: GO:0031571
    annotations:
      function:
        tag: function
        value: ensures DNA properly replicated
      regulator:
        tag: regulator
        value: p53, CHK1, CHK2
    title: mitotic G1 DNA damage checkpoint signaling
  SPINDLE_CHECKPOINT:
    text: SPINDLE_CHECKPOINT
    description: Spindle checkpoint (M checkpoint)
    meaning: GO:0031577
    annotations:
      aliases:
        tag: aliases
        value: SAC, spindle assembly checkpoint
      function:
        tag: function
        value: ensures proper chromosome attachment
      regulator:
        tag: regulator
        value: MAD2, BubR1
    title: spindle checkpoint signaling