Enum: CellCycleRegulator

Types of cell cycle regulatory molecules

Permissible Values

Value	Meaning	Description
CYCLIN	GO:0016538	Cyclin proteins
CDK	GO:0004693	Cyclin-dependent kinase
CDK_INHIBITOR	GO:0004861	CDK inhibitor
CHECKPOINT_KINASE	GO:0000077	Checkpoint kinase
TUMOR_SUPPRESSOR	GO:0051726	Tumor suppressor involved in cell cycle
E3_UBIQUITIN_LIGASE	GO:0051437	E3 ubiquitin ligase (cell cycle)
PHOSPHATASE	GO:0004721	Cell cycle phosphatase

Slots

Name	Description
cell_cycle_regulator	Types of cell cycle regulatory molecules

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: CellCycleRegulator
description: Types of cell cycle regulatory molecules
from_schema: https://w3id.org/linkml/valuesets
rank: 1000
permissible_values:
  CYCLIN:
    text: CYCLIN
    description: Cyclin proteins
    meaning: GO:0016538
    annotations:
      examples:
        tag: examples
        value: Cyclin A, B, D, E
    title: cyclin-dependent protein serine/threonine kinase regulator activity
  CDK:
    text: CDK
    description: Cyclin-dependent kinase
    meaning: GO:0004693
    annotations:
      examples:
        tag: examples
        value: CDK1, CDK2, CDK4, CDK6
    title: cyclin-dependent protein serine/threonine kinase activity
  CDK_INHIBITOR:
    text: CDK_INHIBITOR
    description: CDK inhibitor
    meaning: GO:0004861
    annotations:
      examples:
        tag: examples
        value: p21, p27, p57
    title: cyclin-dependent protein serine/threonine kinase inhibitor activity
  CHECKPOINT_KINASE:
    text: CHECKPOINT_KINASE
    description: Checkpoint kinase
    meaning: GO:0000077
    annotations:
      examples:
        tag: examples
        value: CHK1, CHK2, ATR, ATM
    title: DNA damage checkpoint signaling
  TUMOR_SUPPRESSOR:
    text: TUMOR_SUPPRESSOR
    description: Tumor suppressor involved in cell cycle
    meaning: GO:0051726
    annotations:
      examples:
        tag: examples
        value: p53, Rb, BRCA1, BRCA2
    title: regulation of cell cycle
  E3_UBIQUITIN_LIGASE:
    text: E3_UBIQUITIN_LIGASE
    description: E3 ubiquitin ligase (cell cycle)
    meaning: GO:0051437
    annotations:
      examples:
        tag: examples
        value: APC/C, SCF
    title: obsolete positive regulation of ubiquitin-protein ligase activity involved
      in regulation of mitotic cell cycle transition
  PHOSPHATASE:
    text: PHOSPHATASE
    description: Cell cycle phosphatase
    meaning: GO:0004721
    annotations:
      examples:
        tag: examples
        value: CDC25A, CDC25B, CDC25C
    title: phosphoprotein phosphatase activity