Enum: DownstreamProcessEnum

Downstream processing unit operations

URI: valuesets:DownstreamProcessEnum

View in BioPortal

Permissible Values

Value	Title	Meaning	Description	Agents	Aliases	Methods	Mwco	Principle	Types
CENTRIFUGATION	analytical centrifugation	CHMO:0002010	Centrifugal separation					Density difference	Disk stack, tubular, decanter
FILTRATION		CHMO:0001640	Filtration (micro/ultra/nano)						Dead-end, crossflow, depth
CHROMATOGRAPHY		CHMO:0001000	Chromatographic separation						Ion exchange, affinity, size exclusion
EXTRACTION		CHMO:0001577	Liquid-liquid extraction					Partitioning between phases
PRECIPITATION		CHMO:0001688	Precipitation/crystallization	Salts, solvents, pH
EVAPORATION		CHMO:0001574	Evaporation/concentration						Falling film, MVR, TVR
DISTILLATION	continuous distillation	CHMO:0001534	Distillation					Boiling point difference
DRYING	direct drying	CHMO:0001551	Drying operations						Spray, freeze, vacuum
HOMOGENIZATION			Cell disruption/homogenization			High pressure, bead mill
CLARIFICATION			Removal of cells and debris to produce a clarified harvest			Centrifugation, depth filtration
FLOCCULATION			Aggregation of cells and debris into flocs to aid clarification
ULTRAFILTRATION	ultra-filtration	CHMO:0001645	Membrane concentration retaining macromolecules such as proteins				Typically 1-1000 kDa
DIAFILTRATION			Buffer exchange and desalting by ultrafiltration with continuous makeup
TANGENTIAL_FLOW_FILTRATION			Crossflow membrane filtration used for concentration and diafiltration		TFF, crossflow filtration
BUFFER_EXCHANGE			Replacement of the buffer matrix of a product stream
ADSORPTION			Capture of product or impurities onto a solid sorbent
VIRAL_INACTIVATION			Treatment step that inactivates potential viral contaminants			Low pH, solvent/detergent, heat
POLISHING			Final chromatographic or filtration steps to remove trace impurities
LYOPHILIZATION	freeze drying	CHMO:0001553	Freeze-drying to produce a stable solid product		freeze drying

Slots

Name	Description
downstream_process	Downstream processing unit operations

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/valuesets

LinkML Source

name: DownstreamProcessEnum
instantiates:
- valuesets_meta:ValueSetEnumDefinition
description: Downstream processing unit operations
title: Downstream Process
from_schema: https://w3id.org/valuesets
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: DRAFT
rank: 1000
permissible_values:
  CENTRIFUGATION:
    text: CENTRIFUGATION
    description: Centrifugal separation
    meaning: CHMO:0002010
    annotations:
      principle:
        tag: principle
        value: Density difference
      types:
        tag: types
        value: Disk stack, tubular, decanter
    title: analytical centrifugation
  FILTRATION:
    text: FILTRATION
    description: Filtration (micro/ultra/nano)
    meaning: CHMO:0001640
    annotations:
      types:
        tag: types
        value: Dead-end, crossflow, depth
  CHROMATOGRAPHY:
    text: CHROMATOGRAPHY
    description: Chromatographic separation
    meaning: CHMO:0001000
    annotations:
      types:
        tag: types
        value: Ion exchange, affinity, size exclusion
  EXTRACTION:
    text: EXTRACTION
    description: Liquid-liquid extraction
    meaning: CHMO:0001577
    annotations:
      principle:
        tag: principle
        value: Partitioning between phases
  PRECIPITATION:
    text: PRECIPITATION
    description: Precipitation/crystallization
    meaning: CHMO:0001688
    annotations:
      agents:
        tag: agents
        value: Salts, solvents, pH
  EVAPORATION:
    text: EVAPORATION
    description: Evaporation/concentration
    meaning: CHMO:0001574
    annotations:
      types:
        tag: types
        value: Falling film, MVR, TVR
  DISTILLATION:
    text: DISTILLATION
    description: Distillation
    meaning: CHMO:0001534
    annotations:
      principle:
        tag: principle
        value: Boiling point difference
    title: continuous distillation
  DRYING:
    text: DRYING
    description: Drying operations
    meaning: CHMO:0001551
    annotations:
      types:
        tag: types
        value: Spray, freeze, vacuum
    title: direct drying
  HOMOGENIZATION:
    text: HOMOGENIZATION
    description: Cell disruption/homogenization
    annotations:
      methods:
        tag: methods
        value: High pressure, bead mill
  CLARIFICATION:
    text: CLARIFICATION
    description: Removal of cells and debris to produce a clarified harvest
    annotations:
      methods:
        tag: methods
        value: Centrifugation, depth filtration
  FLOCCULATION:
    text: FLOCCULATION
    description: Aggregation of cells and debris into flocs to aid clarification
  ULTRAFILTRATION:
    text: ULTRAFILTRATION
    description: Membrane concentration retaining macromolecules such as proteins
    meaning: CHMO:0001645
    annotations:
      mwco:
        tag: mwco
        value: Typically 1-1000 kDa
    title: ultra-filtration
  DIAFILTRATION:
    text: DIAFILTRATION
    description: Buffer exchange and desalting by ultrafiltration with continuous
      makeup
  TANGENTIAL_FLOW_FILTRATION:
    text: TANGENTIAL_FLOW_FILTRATION
    description: Crossflow membrane filtration used for concentration and diafiltration
    annotations:
      aliases:
        tag: aliases
        value: TFF, crossflow filtration
  BUFFER_EXCHANGE:
    text: BUFFER_EXCHANGE
    description: Replacement of the buffer matrix of a product stream
  ADSORPTION:
    text: ADSORPTION
    description: Capture of product or impurities onto a solid sorbent
  VIRAL_INACTIVATION:
    text: VIRAL_INACTIVATION
    description: Treatment step that inactivates potential viral contaminants
    annotations:
      methods:
        tag: methods
        value: Low pH, solvent/detergent, heat
  POLISHING:
    text: POLISHING
    description: Final chromatographic or filtration steps to remove trace impurities
  LYOPHILIZATION:
    text: LYOPHILIZATION
    description: Freeze-drying to produce a stable solid product
    meaning: CHMO:0001553
    annotations:
      aliases:
        tag: aliases
        value: freeze drying
    title: freeze drying