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Enum: INRGSSStage

International Neuroblastoma Risk Group Staging System (INRGSS) stages. A clinical staging system based on imaging and image-defined risk factors (IDRFs), effective for diagnosis years 2024+. Allows staging before any treatment, unlike the surgical INSS system.

URI: valuesets:INRGSSStage

Permissible Values

Value Meaning Description
L1 NCIT:C133427 Localized tumor not involving vital structures as defined by the list of imag...
L2 NCIT:C133428 Locoregional tumor with presence of one or more image-defined risk factors
M NCIT:C133429 Distant metastatic disease (except as defined for MS)
MS NCIT:C133430 Metastatic disease in children younger than 18 months with metastases confine...

See Also

Identifier and Mapping Information

Annotations

property value
source SEER/INRG Task Force
effective_year 2024
staging_basis imaging

Schema Source

  • from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: INRGSSStage
instantiates:
- valuesets_meta:ValueSetEnumDefinition
annotations:
  source:
    tag: source
    value: SEER/INRG Task Force
  effective_year:
    tag: effective_year
    value: 2024
  staging_basis:
    tag: staging_basis
    value: imaging
description: International Neuroblastoma Risk Group Staging System (INRGSS) stages.
  A clinical staging system based on imaging and image-defined risk factors (IDRFs),
  effective for diagnosis years 2024+. Allows staging before any treatment, unlike
  the surgical INSS system.
title: INRGSS Stage
from_schema: https://w3id.org/linkml/valuesets
see_also:
- https://staging.seer.cancer.gov/pediatric/input/1.0/neuroblastoma/inrgss/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2650389/
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: RELEASED
rank: 1000
permissible_values:
  L1:
    text: L1
    description: Localized tumor not involving vital structures as defined by the
      list of image-defined risk factors and confined to one body compartment (neck,
      chest, abdomen, or pelvis).
    meaning: NCIT:C133427
    annotations:
      localized:
        tag: localized
        value: true
      idrfs_present:
        tag: idrfs_present
        value: false
    title: L1 - Localized, no IDRFs
  L2:
    text: L2
    description: Locoregional tumor with presence of one or more image-defined risk
      factors. The tumor has not spread far from where it started but has at least
      one IDRF.
    meaning: NCIT:C133428
    annotations:
      localized:
        tag: localized
        value: true
      idrfs_present:
        tag: idrfs_present
        value: true
    title: L2 - Localized, with IDRFs
  M:
    text: M
    description: Distant metastatic disease (except as defined for MS). The tumor
      has spread (metastasized) to distant parts of the body.
    meaning: NCIT:C133429
    annotations:
      metastatic:
        tag: metastatic
        value: true
    title: M - Metastatic
  MS:
    text: MS
    description: Metastatic disease in children younger than 18 months with metastases
      confined to skin, liver, and/or bone marrow (bone marrow involvement limited
      to <10% tumor cells). This stage has a favorable prognosis despite metastatic
      disease.
    meaning: NCIT:C133430
    annotations:
      metastatic:
        tag: metastatic
        value: true
      special_category:
        tag: special_category
        value: true
      age_restriction:
        tag: age_restriction
        value: <18 months
      favorable_prognosis:
        tag: favorable_prognosis
        value: true
    title: MS - Metastatic special
    aliases:
    - Stage 4S equivalent