Enum: INSSStage

International Neuroblastoma Staging System (INSS) stages. A post-surgical staging system based on extent of tumor resection, lymph node involvement, and metastatic spread. This is the legacy system; INRGSS is now preferred for diagnosis years 2024+.

URI: valuesets:INSSStage

Permissible Values

Value	Meaning	Description
STAGE_1	NCIT:C6639	Localized tumor with complete gross excision, with or without microscopic res...
STAGE_2A	NCIT:C6640	Localized tumor with incomplete gross excision; representative ipsilateral no...
STAGE_2B	NCIT:C6641	Localized tumor with or without complete gross excision, with ipsilateral non...
STAGE_3	NCIT:C6642	Unresectable unilateral tumor infiltrating across the midline, with or withou...
STAGE_4	NCIT:C6643	Any primary tumor with dissemination to distant lymph nodes, bone, bone marro...
STAGE_4S	NCIT:C6644	Localized primary tumor (as defined for stage 1, 2A, or 2B) with disseminatio...

See Also

• https://www.ncbi.nlm.nih.gov/books/NBK65747.5/table/CDR0000062786__725/
• https://www.cancer.org/cancer/types/neuroblastoma/detection-diagnosis-staging/staging.html

Identifier and Mapping Information

Annotations

property	value
source	INSS Consensus Conference
staging_basis	surgical
legacy_system	True

Schema Source

• from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: INSSStage
instantiates:
- valuesets_meta:ValueSetEnumDefinition
annotations:
  source:
    tag: source
    value: INSS Consensus Conference
  staging_basis:
    tag: staging_basis
    value: surgical
  legacy_system:
    tag: legacy_system
    value: true
description: International Neuroblastoma Staging System (INSS) stages. A post-surgical
  staging system based on extent of tumor resection, lymph node involvement, and metastatic
  spread. This is the legacy system; INRGSS is now preferred for diagnosis years 2024+.
title: INSS Stage
from_schema: https://w3id.org/linkml/valuesets
see_also:
- https://www.ncbi.nlm.nih.gov/books/NBK65747.5/table/CDR0000062786__725/
- https://www.cancer.org/cancer/types/neuroblastoma/detection-diagnosis-staging/staging.html
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: RELEASED
rank: 1000
permissible_values:
  STAGE_1:
    text: STAGE_1
    description: Localized tumor with complete gross excision, with or without microscopic
      residual disease; representative ipsilateral lymph nodes negative for tumor
      microscopically.
    meaning: NCIT:C6639
    annotations:
      localized:
        tag: localized
        value: true
      resection:
        tag: resection
        value: complete
    title: Stage 1
  STAGE_2A:
    text: STAGE_2A
    description: Localized tumor with incomplete gross excision; representative ipsilateral
      nonadherent lymph nodes negative for tumor microscopically.
    meaning: NCIT:C6640
    annotations:
      localized:
        tag: localized
        value: true
      resection:
        tag: resection
        value: incomplete
      lymph_nodes:
        tag: lymph_nodes
        value: negative
    title: Stage 2A
  STAGE_2B:
    text: STAGE_2B
    description: Localized tumor with or without complete gross excision, with ipsilateral
      nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes
      must be negative microscopically.
    meaning: NCIT:C6641
    annotations:
      localized:
        tag: localized
        value: true
      lymph_nodes:
        tag: lymph_nodes
        value: ipsilateral_positive
    title: Stage 2B
  STAGE_3:
    text: STAGE_3
    description: Unresectable unilateral tumor infiltrating across the midline, with
      or without regional lymph node involvement; or localized unilateral tumor with
      contralateral regional lymph node involvement; or midline tumor with bilateral
      extension by infiltration (unresectable) or by lymph node involvement.
    meaning: NCIT:C6642
    annotations:
      localized:
        tag: localized
        value: false
      crosses_midline:
        tag: crosses_midline
        value: true
    title: Stage 3
  STAGE_4:
    text: STAGE_4
    description: Any primary tumor with dissemination to distant lymph nodes, bone,
      bone marrow, liver, skin, and/or other organs (except as defined for stage 4S).
    meaning: NCIT:C6643
    annotations:
      metastatic:
        tag: metastatic
        value: true
    title: Stage 4
  STAGE_4S:
    text: STAGE_4S
    description: Localized primary tumor (as defined for stage 1, 2A, or 2B) with
      dissemination limited to skin, liver, and/or bone marrow (limited to infants
      <1 year of age). Marrow involvement should be minimal (<10% of total nucleated
      cells).
    meaning: NCIT:C6644
    annotations:
      metastatic:
        tag: metastatic
        value: true
      special_category:
        tag: special_category
        value: true
      age_restriction:
        tag: age_restriction
        value: <12 months
      favorable_prognosis:
        tag: favorable_prognosis
        value: true
    title: Stage 4S
    aliases:
    - Special stage 4