Enum: NeuroblastomaRiskGroup

International Neuroblastoma Risk Group (INRG) pretreatment risk classification groups. Combines INRGSS stage with tumor histology, MYCN status, ploidy, and other prognostic factors.

URI: valuesets:NeuroblastomaRiskGroup

Permissible Values

Value	Meaning	Description
VERY_LOW	NCIT:C103236	Very low risk neuroblastoma with excellent prognosis
LOW	NCIT:C103237	Low risk neuroblastoma with favorable prognosis
INTERMEDIATE	NCIT:C103238	Intermediate risk neuroblastoma requiring multimodal treatment including chem...
HIGH	NCIT:C103239	High risk neuroblastoma with poor prognosis

See Also

• https://pmc.ncbi.nlm.nih.gov/articles/PMC2650388/

Identifier and Mapping Information

Annotations

property	value
source	INRG Task Force

Schema Source

• from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: NeuroblastomaRiskGroup
instantiates:
- valuesets_meta:ValueSetEnumDefinition
annotations:
  source:
    tag: source
    value: INRG Task Force
description: International Neuroblastoma Risk Group (INRG) pretreatment risk classification
  groups. Combines INRGSS stage with tumor histology, MYCN status, ploidy, and other
  prognostic factors.
title: Neuroblastoma Risk Group
from_schema: https://w3id.org/linkml/valuesets
see_also:
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2650388/
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: RELEASED
rank: 1000
permissible_values:
  VERY_LOW:
    text: VERY_LOW
    description: Very low risk neuroblastoma with excellent prognosis. Typically includes
      L1 tumors and MS without MYCN amplification.
    meaning: NCIT:C103236
    annotations:
      expected_efs:
        tag: expected_efs
        value: '>85%'
    title: Very Low Risk
  LOW:
    text: LOW
    description: Low risk neuroblastoma with favorable prognosis. Treatment may include
      surgery alone or observation.
    meaning: NCIT:C103237
    annotations:
      expected_efs:
        tag: expected_efs
        value: '>75%'
    title: Low Risk
  INTERMEDIATE:
    text: INTERMEDIATE
    description: Intermediate risk neuroblastoma requiring multimodal treatment including
      chemotherapy.
    meaning: NCIT:C103238
    annotations:
      expected_efs:
        tag: expected_efs
        value: 50-75%
    title: Intermediate Risk
  HIGH:
    text: HIGH
    description: High risk neuroblastoma with poor prognosis. Requires intensive multimodal
      therapy including high-dose chemotherapy with autologous stem cell rescue, surgery,
      radiation, and immunotherapy.
    meaning: NCIT:C103239
    annotations:
      expected_efs:
        tag: expected_efs
        value: <50%
      mycn_amplified:
        tag: mycn_amplified
        value: often
    title: High Risk