Enum: PediatricOncologyDiagnosisCategory
High-level groupings for pediatric cancer diagnoses per CCDI CDE 16607972. Designed for cohort aggregation across federated data resources. Each diagnosis maps to a single dominant category.
URI: valuesets:PediatricOncologyDiagnosisCategory
Permissible Values
| Value | Meaning | Description |
|---|---|---|
| ATYPICAL_TERATOID_RHABDOID_TUMOR | NCIT:C6807 | Highly malignant embryonal CNS tumor characterized by loss of SMARCB1 (INI1) ... |
| CHOROID_PLEXUS_TUMOR | NCIT:C3698 | Neoplasms arising from the choroid plexus epithelium, including papilloma, at... |
| CNS_GERM_CELL_TUMOR | NCIT:C6286 | Germ cell tumors arising within the central nervous system, including germino... |
| CNS_SARCOMA | NCIT:C121624 | Sarcomas arising primarily in the central nervous system, including Ewing sar... |
| CRANIOPHARYNGIOMA | NCIT:C2998 | Benign epithelial tumors arising from remnants of Rathke pouch, including ada... |
| EPENDYMOMA | NCIT:C3017 | Glial tumors arising from ependymal cells lining the ventricular system and c... |
| GLIONEURONAL_AND_NEURONAL_TUMOR | NCIT:C6927 | Tumors with neuronal differentiation including ganglioglioma, dysembryoplasti... |
| HIGH_GRADE_GLIOMA | NCIT:C129355 | Aggressive glial tumors including pediatric-type diffuse high-grade gliomas (... |
| LOW_GRADE_GLIOMA | NCIT:C129354 | Indolent glial tumors including pilocytic astrocytoma and pediatric-type diff... |
| MEDULLOBLASTOMA | NCIT:C3222 | Embryonal tumor of the cerebellum, classified by molecular subgroups (WNT-act... |
| OTHER_CNS_EMBRYONAL_TUMOR | NCIT:C6774 | Embryonal tumors of the CNS other than medulloblastoma and ATRT, including em... |
| OTHER_GLIOMA | NCIT:C3059 | Glial tumors not classified as high-grade or low-grade glioma, including angi... |
| OTHER_BRAIN_TUMOR | NCIT:C2907 | CNS tumors not fitting other brain tumor categories, including meningioma, sc... |
| LYMPHOBLASTIC_LEUKEMIA | NCIT:C3167 | Acute lymphoblastic leukemia (ALL) including B-ALL and T-ALL with all molecul... |
| MYELOID_LEUKEMIA | NCIT:C3171 | Acute myeloid leukemia (AML) and related myeloid neoplasms including AML with... |
| HODGKIN_LYMPHOMA | NCIT:C9357 | Lymphoid neoplasm characterized by Reed-Sternberg cells, including classical ... |
| NON_HODGKIN_LYMPHOMA | NCIT:C3211 | Lymphoid neoplasms other than Hodgkin lymphoma, including Burkitt lymphoma, d... |
| LYMPHOPROLIFERATIVE_DISEASE | NCIT:C3138 | Disorders characterized by abnormal lymphocyte proliferation, including post-... |
| OTHER_HEME_TUMOR | NCIT:C27134 | Hematologic malignancies not classified elsewhere, including histiocytic diso... |
| NEUROBLASTOMA | NCIT:C3270 | Embryonal tumor of the peripheral sympathetic nervous system, arising from ne... |
| OSTEOSARCOMA | NCIT:C9145 | Primary malignant bone tumor characterized by osteoid production, including c... |
| EWING_SARCOMA | NCIT:C4817 | Small round cell sarcoma typically harboring EWSR1 rearrangements, arising in... |
| RHABDOMYOSARCOMA | NCIT:C3359 | Malignant soft tissue tumor with skeletal muscle differentiation, including e... |
| SOFT_TISSUE_TUMOR | NCIT:C3399 | Soft tissue neoplasms other than rhabdomyosarcoma and Ewing sarcoma, includin... |
| RHABDOID_TUMOR | NCIT:C3769 | Highly aggressive tumors characterized by SMARCB1 loss, occurring outside the... |
| RENAL_TUMOR | NCIT:C7548 | Kidney tumors including Wilms tumor (nephroblastoma), clear cell sarcoma of k... |
| RETINOBLASTOMA | NCIT:C7541 | Malignant neoplasm of the retina arising from developing retinal cells, assoc... |
| GERM_CELL_TUMOR | NCIT:C3708 | Tumors arising from primordial germ cells, occurring in gonadal or extragonad... |
| ENDOCRINE_AND_NEUROENDOCRINE_TUMOR | NCIT:C3010 | Tumors of endocrine glands and neuroendocrine cells, including thyroid carcin... |
| OTHER_SOLID_TUMOR | NCIT:C9107 | Solid tumors not classified elsewhere, including hepatoblastoma, pleuropulmon... |
See Also
Identifier and Mapping Information
Annotations
| property | value |
|---|---|
| caDSR_CDE | 16607972 |
| source | CCDI Federation API |
| alignment | WHO CNS5, WHO-HAEM5, WHO Pediatric Blue Book |
Schema Source
- from schema: https://w3id.org/linkml/valuesets
LinkML Source
name: PediatricOncologyDiagnosisCategory
instantiates:
- valuesets_meta:ValueSetEnumDefinition
annotations:
caDSR_CDE:
tag: caDSR_CDE
value: '16607972'
source:
tag: source
value: CCDI Federation API
alignment:
tag: alignment
value: WHO CNS5, WHO-HAEM5, WHO Pediatric Blue Book
description: High-level groupings for pediatric cancer diagnoses per CCDI CDE 16607972.
Designed for cohort aggregation across federated data resources. Each diagnosis
maps to a single dominant category.
title: Pediatric Oncology Diagnosis Category
from_schema: https://w3id.org/linkml/valuesets
see_also:
- https://github.com/CBIIT/ccdi-federation-api/discussions/160
- https://docs.stjude.cloud/cc4k
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: RELEASED
rank: 1000
permissible_values:
ATYPICAL_TERATOID_RHABDOID_TUMOR:
text: ATYPICAL_TERATOID_RHABDOID_TUMOR
description: Highly malignant embryonal CNS tumor characterized by loss of SMARCB1
(INI1) or SMARCA4 expression. Predominantly occurs in young children.
meaning: NCIT:C6807
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Atypical Teratoid/Rhabdoid Tumors
CHOROID_PLEXUS_TUMOR:
text: CHOROID_PLEXUS_TUMOR
description: Neoplasms arising from the choroid plexus epithelium, including papilloma,
atypical papilloma, and carcinoma.
meaning: NCIT:C3698
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Choroid Plexus Tumors
CNS_GERM_CELL_TUMOR:
text: CNS_GERM_CELL_TUMOR
description: Germ cell tumors arising within the central nervous system, including
germinoma and non-germinomatous germ cell tumors.
meaning: NCIT:C6286
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: CNS Germ Cell Tumors
CNS_SARCOMA:
text: CNS_SARCOMA
description: Sarcomas arising primarily in the central nervous system, including
Ewing sarcoma and rhabdomyosarcoma of CNS.
meaning: NCIT:C121624
annotations:
category:
tag: category
value: brain_tumor
title: CNS Sarcomas
CRANIOPHARYNGIOMA:
text: CRANIOPHARYNGIOMA
description: Benign epithelial tumors arising from remnants of Rathke pouch, including
adamantinomatous and papillary subtypes.
meaning: NCIT:C2998
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Craniopharyngiomas
EPENDYMOMA:
text: EPENDYMOMA
description: Glial tumors arising from ependymal cells lining the ventricular
system and central canal. Includes molecular subtypes defined by WHO CNS5.
meaning: NCIT:C3017
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Ependymoma
GLIONEURONAL_AND_NEURONAL_TUMOR:
text: GLIONEURONAL_AND_NEURONAL_TUMOR
description: Tumors with neuronal differentiation including ganglioglioma, dysembryoplastic
neuroepithelial tumor (DNET), and central neurocytoma.
meaning: NCIT:C6927
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Glioneuronal and Neuronal Tumors
HIGH_GRADE_GLIOMA:
text: HIGH_GRADE_GLIOMA
description: Aggressive glial tumors including pediatric-type diffuse high-grade
gliomas (H3 K27-altered, H3 G34-mutant, and H3/IDH-wildtype), as well as glioblastoma.
meaning: NCIT:C129355
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
grade:
tag: grade
value: high
title: High-Grade Gliomas
LOW_GRADE_GLIOMA:
text: LOW_GRADE_GLIOMA
description: Indolent glial tumors including pilocytic astrocytoma and pediatric-type
diffuse low-grade gliomas (MYB/MYBL1-altered, MAPK pathway-altered).
meaning: NCIT:C129354
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
grade:
tag: grade
value: low
title: Low-Grade Gliomas
MEDULLOBLASTOMA:
text: MEDULLOBLASTOMA
description: Embryonal tumor of the cerebellum, classified by molecular subgroups
(WNT-activated, SHH-activated, Group 3, Group 4) per WHO CNS5.
meaning: NCIT:C3222
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Medulloblastoma
OTHER_CNS_EMBRYONAL_TUMOR:
text: OTHER_CNS_EMBRYONAL_TUMOR
description: Embryonal tumors of the CNS other than medulloblastoma and ATRT,
including embryonal tumor with multilayered rosettes (ETMR), CNS neuroblastoma,
and pineoblastoma.
meaning: NCIT:C6774
annotations:
category:
tag: category
value: brain_tumor
who_classification:
tag: who_classification
value: WHO CNS5
title: Other CNS Embryonal Tumors
aliases:
- CNS Embryonal Tumor, NOS
OTHER_GLIOMA:
text: OTHER_GLIOMA
description: Glial tumors not classified as high-grade or low-grade glioma, including
angiocentric glioma and astroblastoma.
meaning: NCIT:C3059
annotations:
category:
tag: category
value: brain_tumor
title: Other Gliomas
OTHER_BRAIN_TUMOR:
text: OTHER_BRAIN_TUMOR
description: CNS tumors not fitting other brain tumor categories, including meningioma,
schwannoma, and hemangioblastoma.
meaning: NCIT:C2907
annotations:
category:
tag: category
value: brain_tumor
title: Other Brain Tumors
LYMPHOBLASTIC_LEUKEMIA:
text: LYMPHOBLASTIC_LEUKEMIA
description: Acute lymphoblastic leukemia (ALL) including B-ALL and T-ALL with
all molecular subtypes (BCR::ABL1, ETV6::RUNX1, KMT2A-r, DUX4, MEF2D, etc.).
meaning: NCIT:C3167
annotations:
category:
tag: category
value: hematologic
who_classification:
tag: who_classification
value: WHO-HAEM5
title: Lymphoblastic Leukemia
aliases:
- ALL
- Acute Lymphoblastic Leukemia
MYELOID_LEUKEMIA:
text: MYELOID_LEUKEMIA
description: Acute myeloid leukemia (AML) and related myeloid neoplasms including
AML with defining genetic abnormalities, therapy-related AML, and juvenile myelomonocytic
leukemia (JMML).
meaning: NCIT:C3171
annotations:
category:
tag: category
value: hematologic
who_classification:
tag: who_classification
value: WHO-HAEM5
title: Myeloid Leukemia
aliases:
- AML
- Acute Myeloid Leukemia
HODGKIN_LYMPHOMA:
text: HODGKIN_LYMPHOMA
description: Lymphoid neoplasm characterized by Reed-Sternberg cells, including
classical Hodgkin lymphoma and nodular lymphocyte predominant Hodgkin lymphoma.
meaning: NCIT:C9357
annotations:
category:
tag: category
value: hematologic
who_classification:
tag: who_classification
value: WHO-HAEM5
title: Hodgkin Lymphoma
NON_HODGKIN_LYMPHOMA:
text: NON_HODGKIN_LYMPHOMA
description: Lymphoid neoplasms other than Hodgkin lymphoma, including Burkitt
lymphoma, diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and
lymphoblastic lymphoma.
meaning: NCIT:C3211
annotations:
category:
tag: category
value: hematologic
who_classification:
tag: who_classification
value: WHO-HAEM5
title: Non-Hodgkin Lymphoma
aliases:
- NHL
LYMPHOPROLIFERATIVE_DISEASE:
text: LYMPHOPROLIFERATIVE_DISEASE
description: Disorders characterized by abnormal lymphocyte proliferation, including
post-transplant lymphoproliferative disorder (PTLD) and hemophagocytic lymphohistiocytosis
(HLH).
meaning: NCIT:C3138
annotations:
category:
tag: category
value: hematologic
title: Lymphoproliferative Diseases
OTHER_HEME_TUMOR:
text: OTHER_HEME_TUMOR
description: Hematologic malignancies not classified elsewhere, including histiocytic
disorders, myelodysplastic syndromes, and myeloproliferative neoplasms.
meaning: NCIT:C27134
annotations:
category:
tag: category
value: hematologic
title: Other Heme Tumors
NEUROBLASTOMA:
text: NEUROBLASTOMA
description: Embryonal tumor of the peripheral sympathetic nervous system, arising
from neural crest cells. Includes ganglioneuroblastoma and ganglioneuroma.
meaning: NCIT:C3270
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Pediatric Blue Book
title: Neuroblastoma
OSTEOSARCOMA:
text: OSTEOSARCOMA
description: Primary malignant bone tumor characterized by osteoid production,
including conventional, telangiectatic, and small cell variants.
meaning: NCIT:C9145
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Bone/Soft Tissue
title: Osteosarcoma
EWING_SARCOMA:
text: EWING_SARCOMA
description: Small round cell sarcoma typically harboring EWSR1 rearrangements,
arising in bone or soft tissue. Includes Ewing sarcoma family of tumors.
meaning: NCIT:C4817
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Bone/Soft Tissue
title: Ewing Sarcoma
RHABDOMYOSARCOMA:
text: RHABDOMYOSARCOMA
description: Malignant soft tissue tumor with skeletal muscle differentiation,
including embryonal, alveolar, and spindle cell/sclerosing subtypes.
meaning: NCIT:C3359
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Bone/Soft Tissue
title: Rhabdomyosarcoma
SOFT_TISSUE_TUMOR:
text: SOFT_TISSUE_TUMOR
description: Soft tissue neoplasms other than rhabdomyosarcoma and Ewing sarcoma,
including synovial sarcoma, fibrosarcoma, and other sarcomas. Also includes
non-sarcomatous soft tissue tumors.
meaning: NCIT:C3399
annotations:
category:
tag: category
value: solid_tumor
title: Soft Tissue Tumors
aliases:
- Soft Tissue Sarcoma
RHABDOID_TUMOR:
text: RHABDOID_TUMOR
description: Highly aggressive tumors characterized by SMARCB1 loss, occurring
outside the CNS (extracranial rhabdoid tumor). Includes malignant rhabdoid tumor
of kidney.
meaning: NCIT:C3769
annotations:
category:
tag: category
value: solid_tumor
title: Rhabdoid Tumors
RENAL_TUMOR:
text: RENAL_TUMOR
description: Kidney tumors including Wilms tumor (nephroblastoma), clear cell
sarcoma of kidney, renal cell carcinoma, and congenital mesoblastic nephroma.
meaning: NCIT:C7548
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Pediatric Blue Book
title: Renal Tumors
aliases:
- Kidney Tumor
- Wilms Tumor
RETINOBLASTOMA:
text: RETINOBLASTOMA
description: Malignant neoplasm of the retina arising from developing retinal
cells, associated with RB1 mutations.
meaning: NCIT:C7541
annotations:
category:
tag: category
value: solid_tumor
who_classification:
tag: who_classification
value: WHO Pediatric Blue Book
title: Retinoblastoma
GERM_CELL_TUMOR:
text: GERM_CELL_TUMOR
description: Tumors arising from primordial germ cells, occurring in gonadal or
extragonadal sites. Includes teratoma, yolk sac tumor, germinoma, choriocarcinoma,
and mixed germ cell tumors. Excludes CNS germ cell tumors.
meaning: NCIT:C3708
annotations:
category:
tag: category
value: solid_tumor
title: Germ Cell Tumors
ENDOCRINE_AND_NEUROENDOCRINE_TUMOR:
text: ENDOCRINE_AND_NEUROENDOCRINE_TUMOR
description: Tumors of endocrine glands and neuroendocrine cells, including thyroid
carcinoma, adrenocortical carcinoma, pheochromocytoma, and paraganglioma.
meaning: NCIT:C3010
annotations:
category:
tag: category
value: solid_tumor
title: Endocrine and Neuroendocrine Tumors
OTHER_SOLID_TUMOR:
text: OTHER_SOLID_TUMOR
description: Solid tumors not classified elsewhere, including hepatoblastoma,
pleuropulmonary blastoma, nasopharyngeal carcinoma, melanoma, and carcinomas.
meaning: NCIT:C9107
annotations:
category:
tag: category
value: solid_tumor
title: Other Solid Tumors