Enum: StructuralBiologyTechnique

Structural biology experimental techniques

URI: valuesets:StructuralBiologyTechnique

Permissible Values

Value	Title	Meaning	Description	Advantages	Aliases	Applications	Information	Resolution Range
CRYO_EM	cryogenic electron microscopy	CHMO:0002413	Cryo-electron microscopy		cryoEM, electron cryo-microscopy			2-30 Å typical
CRYO_ET	electron tomography	MI:2338	Cryo-electron tomography		cryoET, electron cryo-tomography			20-100 Å typical
X_RAY_CRYSTALLOGRAPHY	single crystal X-ray diffraction	CHMO:0000159	X-ray crystallography		XRC, macromolecular crystallography			1-4 Å typical
NEUTRON_CRYSTALLOGRAPHY	neutron diffraction	CHMO:0000698	Neutron crystallography	hydrogen positions, deuteration studies
SAXS	small-angle X-ray scattering	CHMO:0000204	Small-angle X-ray scattering				low-resolution structure, conformational changes
SANS	small-angle neutron scattering	CHMO:0000184	Small-angle neutron scattering	contrast variation with deuteration
WAXS	wide-angle X-ray scattering	CHMO:0000207	Wide-angle X-ray scattering
NMR	nuclear magnetic resonance spectroscopy	CHMO:0000591	Nuclear magnetic resonance spectroscopy				solution structure, dynamics
MASS_SPECTROMETRY		CHMO:0000470	Mass spectrometry			native MS, crosslinking, HDX
NEGATIVE_STAIN_EM	negative staining	FBbi:00000399	Negative stain electron microscopy					15-30 Å typical

Slots

Name	Description
structural_biology_technique	Structural biology experimental techniques

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: StructuralBiologyTechnique
instantiates:
- valuesets_meta:ValueSetEnumDefinition
description: Structural biology experimental techniques
title: Structural Biology Technique
from_schema: https://w3id.org/linkml/valuesets
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: DRAFT
rank: 1000
permissible_values:
  CRYO_EM:
    text: CRYO_EM
    description: Cryo-electron microscopy
    meaning: CHMO:0002413
    annotations:
      resolution_range:
        tag: resolution_range
        value: 2-30 Å typical
      aliases:
        tag: aliases
        value: cryoEM, electron cryo-microscopy
    title: cryogenic electron microscopy
  CRYO_ET:
    text: CRYO_ET
    description: Cryo-electron tomography
    meaning: MI:2338
    annotations:
      resolution_range:
        tag: resolution_range
        value: 20-100 Å typical
      aliases:
        tag: aliases
        value: cryoET, electron cryo-tomography
    title: electron tomography
  X_RAY_CRYSTALLOGRAPHY:
    text: X_RAY_CRYSTALLOGRAPHY
    description: X-ray crystallography
    meaning: CHMO:0000159
    annotations:
      resolution_range:
        tag: resolution_range
        value: 1-4 Å typical
      aliases:
        tag: aliases
        value: XRC, macromolecular crystallography
    title: single crystal X-ray diffraction
  NEUTRON_CRYSTALLOGRAPHY:
    text: NEUTRON_CRYSTALLOGRAPHY
    description: Neutron crystallography
    meaning: CHMO:0000698
    annotations:
      advantages:
        tag: advantages
        value: hydrogen positions, deuteration studies
    title: neutron diffraction
  SAXS:
    text: SAXS
    description: Small-angle X-ray scattering
    meaning: CHMO:0000204
    annotations:
      information:
        tag: information
        value: low-resolution structure, conformational changes
    title: small-angle X-ray scattering
  SANS:
    text: SANS
    description: Small-angle neutron scattering
    meaning: CHMO:0000184
    annotations:
      advantages:
        tag: advantages
        value: contrast variation with deuteration
    title: small-angle neutron scattering
  WAXS:
    text: WAXS
    description: Wide-angle X-ray scattering
    meaning: CHMO:0000207
    title: wide-angle X-ray scattering
  NMR:
    text: NMR
    description: Nuclear magnetic resonance spectroscopy
    meaning: CHMO:0000591
    annotations:
      information:
        tag: information
        value: solution structure, dynamics
    title: nuclear magnetic resonance spectroscopy
  MASS_SPECTROMETRY:
    text: MASS_SPECTROMETRY
    description: Mass spectrometry
    meaning: CHMO:0000470
    annotations:
      applications:
        tag: applications
        value: native MS, crosslinking, HDX
  NEGATIVE_STAIN_EM:
    text: NEGATIVE_STAIN_EM
    description: Negative stain electron microscopy
    meaning: FBbi:00000399
    annotations:
      resolution_range:
        tag: resolution_range
        value: 15-30 Å typical
    title: negative staining