Enum: StructuralBiologyTechnique

Structural biology experimental techniques

URI: valuesets:StructuralBiologyTechnique

Permissible Values

Value	Meaning	Description
CRYO_EM	CHMO:0002413	Cryo-electron microscopy
CRYO_ET	None	Cryo-electron tomography
X_RAY_CRYSTALLOGRAPHY	CHMO:0000159	X-ray crystallography
NEUTRON_CRYSTALLOGRAPHY	None	Neutron crystallography
SAXS	CHMO:0000204	Small-angle X-ray scattering
SANS	None	Small-angle neutron scattering
WAXS	None	Wide-angle X-ray scattering
NMR	CHMO:0000591	Nuclear magnetic resonance spectroscopy
MASS_SPECTROMETRY	CHMO:0000470	Mass spectrometry
NEGATIVE_STAIN_EM	None	Negative stain electron microscopy

Slots

Name	Description
structural_biology_technique	Structural biology experimental techniques

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/linkml/valuesets

LinkML Source

name: StructuralBiologyTechnique
description: Structural biology experimental techniques
from_schema: https://w3id.org/linkml/valuesets
rank: 1000
permissible_values:
  CRYO_EM:
    text: CRYO_EM
    description: Cryo-electron microscopy
    meaning: CHMO:0002413
    annotations:
      resolution_range:
        tag: resolution_range
        value: 2-30 Å typical
      aliases:
        tag: aliases
        value: cryoEM, electron cryo-microscopy
    title: cryogenic electron microscopy
  CRYO_ET:
    text: CRYO_ET
    description: Cryo-electron tomography
    annotations:
      resolution_range:
        tag: resolution_range
        value: 20-100 Å typical
      aliases:
        tag: aliases
        value: cryoET, electron cryo-tomography
  X_RAY_CRYSTALLOGRAPHY:
    text: X_RAY_CRYSTALLOGRAPHY
    description: X-ray crystallography
    meaning: CHMO:0000159
    annotations:
      resolution_range:
        tag: resolution_range
        value: 1-4 Å typical
      aliases:
        tag: aliases
        value: XRC, macromolecular crystallography
    title: single crystal X-ray diffraction
  NEUTRON_CRYSTALLOGRAPHY:
    text: NEUTRON_CRYSTALLOGRAPHY
    description: Neutron crystallography
    annotations:
      advantages:
        tag: advantages
        value: hydrogen positions, deuteration studies
  SAXS:
    text: SAXS
    description: Small-angle X-ray scattering
    meaning: CHMO:0000204
    annotations:
      information:
        tag: information
        value: low-resolution structure, conformational changes
    title: small-angle X-ray scattering
  SANS:
    text: SANS
    description: Small-angle neutron scattering
    annotations:
      advantages:
        tag: advantages
        value: contrast variation with deuteration
  WAXS:
    text: WAXS
    description: Wide-angle X-ray scattering
  NMR:
    text: NMR
    description: Nuclear magnetic resonance spectroscopy
    meaning: CHMO:0000591
    annotations:
      information:
        tag: information
        value: solution structure, dynamics
    title: nuclear magnetic resonance spectroscopy
  MASS_SPECTROMETRY:
    text: MASS_SPECTROMETRY
    description: Mass spectrometry
    meaning: CHMO:0000470
    annotations:
      applications:
        tag: applications
        value: native MS, crosslinking, HDX
  NEGATIVE_STAIN_EM:
    text: NEGATIVE_STAIN_EM
    description: Negative stain electron microscopy
    annotations:
      resolution_range:
        tag: resolution_range
        value: 15-30 Å typical