Enum: ToxicologyAssayEnum
Assays for evaluating toxicity, genotoxicity, and safety of compounds including cytotoxicity, mutagenicity, and ADME measurements.
URI: valuesets:ToxicologyAssayEnum
Permissible Values
| Value | Meaning | Description | Companion Enum Cell Line | Companion Enum Compound |
|---|---|---|---|---|
| TOXICITY_ASSAY | BAO:0002189 | General assay measuring degree of substance toxicity to living cells | CellType | ChemicalEntity |
| MTT_ASSAY | BAO:0002457 | Colorimetric assay measuring cell metabolic activity via MTT reduction | CellType | ChemicalEntity |
| LDH_RELEASE_ASSAY | BAO:0013056 | Cytotoxicity assay measuring lactate dehydrogenase release from damaged cells | CellType | ChemicalEntity |
| AMES_TEST | BAO:0013054 | Mutagenicity assay using bacterial reverse mutation in Salmonella strains | ChemicalEntity | |
| COMET_ASSAY | OBI:0302736 | Single cell gel electrophoresis assay measuring DNA strand breaks | CellType | ChemicalEntity |
| MICRONUCLEUS_ASSAY | BAO:0013055 | Genotoxicity assay detecting chromosomal damage via micronucleus formation | CellType | ChemicalEntity |
| DOSE_RESPONSE | Measurement of biological response as a function of compound concentration | CellType | ChemicalEntity | |
| ADME_ASSAY | Absorption, distribution, metabolism, and excretion profiling | ChemicalEntity |
Slots
| Name | Description |
|---|---|
| toxicology_assay | Toxicology assay type |
Identifier and Mapping Information
Schema Source
- from schema: https://w3id.org/valuesets
LinkML Source
name: ToxicologyAssayEnum
instantiates:
- valuesets_meta:ValueSetEnumDefinition
description: Assays for evaluating toxicity, genotoxicity, and safety of compounds
including cytotoxicity, mutagenicity, and ADME measurements.
title: Toxicology Assay Types
from_schema: https://w3id.org/valuesets
contributors:
- orcid:0000-0002-6601-2165
- https://github.com/anthropics/claude-code
status: DRAFT
rank: 1000
permissible_values:
TOXICITY_ASSAY:
text: TOXICITY_ASSAY
description: General assay measuring degree of substance toxicity to living cells
meaning: BAO:0002189
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
MTT_ASSAY:
text: MTT_ASSAY
description: Colorimetric assay measuring cell metabolic activity via MTT reduction
meaning: BAO:0002457
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
aliases:
- MTT reduction assay
LDH_RELEASE_ASSAY:
text: LDH_RELEASE_ASSAY
description: Cytotoxicity assay measuring lactate dehydrogenase release from damaged
cells
meaning: BAO:0013056
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
AMES_TEST:
text: AMES_TEST
description: Mutagenicity assay using bacterial reverse mutation in Salmonella
strains
meaning: BAO:0013054
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
COMET_ASSAY:
text: COMET_ASSAY
description: Single cell gel electrophoresis assay measuring DNA strand breaks
meaning: OBI:0302736
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
MICRONUCLEUS_ASSAY:
text: MICRONUCLEUS_ASSAY
description: Genotoxicity assay detecting chromosomal damage via micronucleus
formation
meaning: BAO:0013055
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
DOSE_RESPONSE:
text: DOSE_RESPONSE
description: Measurement of biological response as a function of compound concentration
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity
companion_enum_cell_line:
tag: companion_enum_cell_line
value: CellType
ADME_ASSAY:
text: ADME_ASSAY
description: Absorption, distribution, metabolism, and excretion profiling
annotations:
companion_enum_compound:
tag: companion_enum_compound
value: ChemicalEntity